Antibody to S-100 protein aids the separation of pagetoid melanoma from mammary and extramammary Paget's disease.

@article{Glasgow1987AntibodyTS,
  title={Antibody to S-100 protein aids the separation of pagetoid melanoma from mammary and extramammary Paget's disease.},
  author={Ben J. Glasgow and Dong-dong Wen and S A al-Jitawi and Alistair J. Cochran},
  journal={Journal of cutaneous pathology},
  year={1987},
  volume={14 4},
  pages={223-6}
}
We evaluated the usefulness of immunohistological staining for S-100 protein in differentiating mammary and extramammary Paget's disease from primary malignant melanoma of superficial spreading (pagetoid) type. This technique was compared to both the mucicarmine and periodic acid-Schiff (PAS) methods. The tumor cells of 10 melanomas contained abundant cytoplasmic S-100 protein. In tissues from mammary and extramammary Paget's disease, S-100 protein was detected in myoepithelial cells… CONTINUE READING