Antibody titer threshold predicts anti-candidal vaccine efficacy even though the mechanism of protection is induction of cell-mediated immunity.

@article{Spellberg2008AntibodyTT,
  title={Antibody titer threshold predicts anti-candidal vaccine efficacy even though the mechanism of protection is induction of cell-mediated immunity.},
  author={Brad J. Spellberg and Ashraf S Ibrahim and Lin Lin and Valentina Avanesian and Yue Fu and Peter N Lipke and Henry N Otoo and Tiffany Ho and John E. Edwards},
  journal={The Journal of infectious diseases},
  year={2008},
  volume={197 7},
  pages={967-71}
}
We previously reported that vaccination with Freund's adjuvant plus the recombinant N-terminus of the candidal adhesin, Als3p (rAls3p-N), protects mice from disseminated candidiasis. Here we report that the rAls3p-N vaccine is effective when combined with aluminum hydroxide adjuvant. Antibody titers of > or =1:6400 accurately predicted protection from infection. Nevertheless, neither B lymphocytes nor serum from immunized animals transferred protection to vaccine-naive animals. In contrast, CD3… CONTINUE READING