Antibody tests for identification of current and past infection with SARS‐CoV‐2

@article{Deeks2020AntibodyTF,
  title={Antibody tests for identification of current and past infection with SARS‐CoV‐2},
  author={Jonathan J. Deeks and Jacqueline Dinnes and Yemisi Takwoingi and Clare F Davenport and Ren{\'e} Spijker and Sian Taylor-Phillips and Ada Adriano and Sophie Elizabeth Beese and Janine Dretzke and Lavinia Ferrante di Ruffano and Isobel Marion Harris and Malcolm J Price and Sabine Dittrich and Devy M. Emperador and Lotty Hooft and Mariska M. G. Leeflang and Ann Van den Bruel},
  journal={The Cochrane Database of Systematic Reviews},
  year={2020},
  volume={2020}
}
Abstract Background The severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) virus and resulting COVID‐19 pandemic present important diagnostic challenges. Several diagnostic strategies are available to identify current infection, rule out infection, identify people in need of care escalation, or to test for past infection and immune response. Serology tests to detect the presence of antibodies to SARS‐CoV‐2 aim to identify previous SARS‐CoV‐2 infection, and may help to confirm the… 
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References

SHOWING 1-10 OF 242 REFERENCES
Development and clinical application of a rapid IgM‐IgG combined antibody test for SARS‐CoV‐2 infection diagnosis
TLDR
A rapid and simple point‐of‐care lateral flow immunoassay that can detect immunoglobulin M (IgM) and IgG antibodies simultaneously against SARS‐CoV‐2 virus in human blood within 15 minutes which can detect patients at different infection stages is developed.
Evaluation of the auxiliary diagnostic value of antibody assays for the detection of novel coronavirus (SARS‐CoV‐2)
TLDR
The findings indicate that the antibody detection could be used as an effective supplementary indicator of SARS‐CoV‐2 infection in suspected cases with no detectable viral RNA, and in conjunction with nucleic acid detection in confirming the infection.
Characteristics of patients with coronavirus disease (COVID‐19) confirmed using an IgM‐IgG antibody test
TLDR
It is suggested that patients who develop severe illness might experience longer virus exposure times and develop a more severe inflammatory response.
Serological tests facilitate identification of asymptomatic SARS‐CoV‐2 infection in Wuhan, China
TLDR
The positive rate of COVID-19 tests based on NAT, chest CT scan and a serological SARS-CoV-2 test, from April 3 to 15 in one hospital in Qingshan Destrict, Wuhan, indicates that large-scale investigation is required to evaluate the herd immunity of the city, for the resuming people and for the re-opened city.
SARS-CoV-2 specific antibody responses in COVID-19 patients
TLDR
It is demonstrated that most PCR-confirmed SARS-CoV-2 infected individuals seroconverted, as revealed by sensitive and specific in-house ELISAs, and that commercial S1 IgG or IgA ELisAs were of lower specificity while sensitivity varied between the two, with IgA showing higher sensitivity.
Diagnosis of SARS-CoV-2 infection and COVID-19: accuracy of signs and symptoms; molecular, antigen, and antibody tests; and routine laboratory markers
TLDR
This is a protocol for a Cochrane Review (diagnostic) to assess the diagnostic accuracy of laboratory real-time polymerase chain reaction (RT-PCR) and other laboratory molecular tests to determine if a person presenting in the community or in secondary care has SARS-CoV-2 infection.
A serological assay to detect SARS-CoV-2 seroconversion in humans
TLDR
Serological assays are of critical importance to determine seroprevalence in a given population, define previous exposure and identify highly reactive human donors for the generation of convalescent serum as therapeutic.
Analysis of Serologic Cross-Reactivity Between Common Human Coronaviruses and SARS-CoV-2 Using Coronavirus Antigen Microarray
TLDR
This array can be used to answer outstanding questions regarding SARS-CoV-2 infection, including whether baseline serology for other coronaviruses impacts disease course, how the antibody response to infection develops over time, and what antigens would be optimal for vaccine development.
Neutralizing antibody responses to SARS-CoV-2 in a COVID-19 recovered patient cohort and their implications
TLDR
The variations of SARS-CoV-2 specific NAbs in recovered COVID-19 patients may raise the concern about the role of NAbs on disease progression and the correlation of NAb titers with age, lymphocyte counts, and blood CRP levels suggested that the interplay between virus and host immune response in coronavirus infections should be further explored.
Antibody Detection and Dynamic Characteristics in Patients with COVID-19
TLDR
The antibodies against SARS-CoV-2 can be detected in the middle and later stage of the illness and may play an important role in the diagnosis of COVID-19 as complement approach for viral nucleid acid assays.
...
...