Antibody-targeted myofibroblast apoptosis reduces fibrosis during sustained liver injury.

  title={Antibody-targeted myofibroblast apoptosis reduces fibrosis during sustained liver injury.},
  author={A. Douglass and K. Wallace and Rebecca D. Parr and J. Park and E. Durward and I. Broadbent and C. Barelle and Andrew J. Porter and M. Wright},
  journal={Journal of hepatology},
  volume={49 1},
  • A. Douglass, K. Wallace, +6 authors M. Wright
  • Published 2008
  • Biology, Medicine
  • Journal of hepatology
  • BACKGROUND/AIMS Myofibroblast apoptosis promotes the resolution of liver fibrosis. However, retaining macrophages may enhance reversal. The effects of specifically stimulating myofibroblast apoptosis in vivo were assessed. METHODS A single chain antibody (C1-3) to an extracellular domain of a myofibroblast membrane protein was injected as a fluorescent- or gliotoxin conjugate into mice with liver fibrosis. RESULTS C1-3 specifically targeted alpha-smooth muscle actin positive liver… CONTINUE READING
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