Antibody-targeted drugs and drug resistance--challenges and solutions.

@article{ShefetCarasso2015AntibodytargetedDA,
  title={Antibody-targeted drugs and drug resistance--challenges and solutions.},
  author={Leeron Shefet-Carasso and Itai Benhar},
  journal={Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy},
  year={2015},
  volume={18},
  pages={36-46}
}
Antibody-based therapy of various human malignancies has shown efficacy in the past 30 years and is now one of the most successful and leading strategies for targeted treatment of patients harboring hematological malignancies and solid tumors. Antibody-drug conjugates (ADCs) aim to take advantage of the affinity and specificity of monoclonal antibodies (mAbs) to selectively deliver potent cytotoxic drugs to antigen-expressing tumor cells. Key parameters for ADC include choosing the optimal… CONTINUE READING

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