Antibody responses and avidity of naturally acquired anti-Plasmodium vivax Duffy binding protein (PvDBP) antibodies in individuals from an area with unstable malaria transmission.

@article{Zakeri2011AntibodyRA,
  title={Antibody responses and avidity of naturally acquired anti-Plasmodium vivax Duffy binding protein (PvDBP) antibodies in individuals from an area with unstable malaria transmission.},
  author={Sedigheh Zakeri and Laleh Babaeekhou and Akram Abouie Mehrizi and M. Safeer-Ul-Azeem Abbasi and Navid Dinparast Djadid},
  journal={The American journal of tropical medicine and hygiene},
  year={2011},
  volume={84 6},
  pages={
          944-50
        }
}
Plasmodium vivax remains an important cause of morbidity outside Africa, and no effective vaccine is available against this parasite. The P. vivax Duffy binding protein (PvDBP) is essential during merozoite invasion into erythrocytes, and it is a target for protective immunity against malaria. This investigation was designed to evaluate naturally acquired antibodies to two variant forms of PvDBP-II antigen (DBP-I and -VI) in malaria individuals (N = 85; median = 22 years) who were living in… CONTINUE READING

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Plasmodium vivax clinical malaria is commonly observed in Duffy-negative Malagasy people.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2010