Antibody-regulated neurotoxic function of cell-surface beta-amyloid precursor protein.

  title={Antibody-regulated neurotoxic function of cell-surface beta-amyloid precursor protein.},
  author={Haruka Sudo and Haisong Jiang and Takashi Yasukawa and Yuichi Hashimoto and Takako Niikura and Masaoki Kawasumi and Satoru Matsuda and Yusuke Takeuchi and Sadakazu Aiso and Masaaki Matsuoka and Yoshitake Murayama and Ikuo Nishimoto},
  journal={Molecular and cellular neurosciences},
  volume={16 6},
APP is a transmembrane precursor of beta-amyloid, and its mutations cause early-onset familial Alzheimer's disease. We report a toxic function of normal wild-type APP (wtAPP). Treatment of neuronal F11 cells, immortalized embryonic day 13 neurons, overexpressing wtAPP with anti-APP antibodies caused death. Death was not induced by antibody in parental F11 cells. Death by antibody occurred through cell-surface APP, not through secreted APP, in a pertussis toxin-sensitive manner and was typical… CONTINUE READING
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