Antibody recognition of the pandemic H1N1 Influenza virus hemagglutinin receptor binding site.

@article{Hong2013AntibodyRO,
  title={Antibody recognition of the pandemic H1N1 Influenza virus hemagglutinin receptor binding site.},
  author={Minsun Hong and Peter S Lee and Ryan M. B. Hoffman and Xueyong Zhu and Jens Christian Krause and Nick S. Laursen and Sung-il Yoon and Langzhou Song and Lynda Tussey and James E. Crowe and Andrew B. Ward and Ian A. Wilson},
  journal={Journal of virology},
  year={2013},
  volume={87 22},
  pages={12471-80}
}
Influenza virus is a global health concern due to its unpredictable pandemic potential. This potential threat was realized in 2009 when an H1N1 virus emerged that resembled the 1918 virus in antigenicity but fortunately was not nearly as deadly. 5J8 is a human antibody that potently neutralizes a broad spectrum of H1N1 viruses, including the 1918 and 2009 pandemic viruses. Here, we present the crystal structure of 5J8 Fab in complex with a bacterially expressed and refolded globular head domain… CONTINUE READING
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