Antibody persistence and T-cell balance: two key factors confronting HIV vaccine development.

@article{Lewis2014AntibodyPA,
  title={Antibody persistence and T-cell balance: two key factors confronting HIV vaccine development.},
  author={George K. Lewis and Anthony L. Devico and Robert C. Gallo},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2014},
  volume={111 44},
  pages={15614-21}
}
The quest for a prophylactic AIDS vaccine is ongoing, but it is now clear that the successful vaccine must elicit protective antibody responses. Accordingly, intense efforts are underway to identify immunogens that elicit these responses. Regardless of the mechanism of antibody-mediated protection, be it neutralization, Fc-mediated effector function, or both, antibody persistence and appropriate T-cell help are significant problems confronting the development of a successful AIDS vaccine. Here… CONTINUE READING
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