Antibody neutralization escape mediated by point mutations in the intracytoplasmic tail of human immunodeficiency virus type 1 gp41.

@article{Kalia2005AntibodyNE,
  title={Antibody neutralization escape mediated by point mutations in the intracytoplasmic tail of human immunodeficiency virus type 1 gp41.},
  author={Vandana Kalia and Surojit Sarkar and Phalguni Gupta and Ronald C. Montelaro},
  journal={Journal of virology},
  year={2005},
  volume={79 4},
  pages={2097-107}
}
The persistence of human immunodeficiency virus type 1 (HIV-1) infection in the presence of robust host immunity has been associated in part with variation in viral envelope proteins leading to antigenic variation and escape from neutralizing antibodies. Previous studies of natural neutralization escape mutants have predominantly focused on gp120 and gp41 ectodomain sequence variations that alter antibody binding via changes in conformation or glycosylation pattern of the Env, likely due to the… CONTINUE READING

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