Antibody neutralization and viral virulence in recurring dengue virus type 2 outbreaks.

@article{Wong2007AntibodyNA,
  title={Antibody neutralization and viral virulence in recurring dengue virus type 2 outbreaks.},
  author={S S Wong and Juraina Abd-Jamil and Sazaly AbuBakar},
  journal={Viral immunology},
  year={2007},
  volume={20 3},
  pages={359-68}
}
Outbreaks involving dengue viruses (DENV) of the same genotype occur in a cyclical pattern in Malaysia. Two cycles of outbreaks involving dengue virus type 2 (DENV-2) of the same genotype occurred in the 1990s in the Klang Valley, Malaysia. Sera of patients from the first outbreak and sera of mice inoculated with virus from the same outbreak had poorer neutralization activity against virus of the second outbreak. Conversely, patient sera from the second outbreak showed higher neutralization… CONTINUE READING
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