Antibody multispecificity in immunoassay interference.

  title={Antibody multispecificity in immunoassay interference.},
  author={Stanley S. Levinson},
  journal={Clinical biochemistry},
  volume={25 2},
Recent findings indicate that many endogenous antibodies exhibit multispecificity. These antibodies exhibit a potential for interference with immunoassays. Antibodies that interfere with immunoassays have been called heterophile or heterophilic antibodies. The purpose of this review is: (1) to identify the nature of heterophile antibodies; (2) to delineate the processes that produce them; (3) to examine the mechanisms by which these antibodies cause interference; and (4) to explore how this… CONTINUE READING

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