Antibody modeling assessment II. Structures and models.

@article{Teplyakov2014AntibodyMA,
  title={Antibody modeling assessment II. Structures and models.},
  author={Alexey Teplyakov and Jinquan Luo and Galina Obmolova and Thomas J. Malia and Raymond W. Sweet and Robyn L Stanfield and Sreekumar R Kodangattil and J. Almagro and Gary L Gilliland},
  journal={Proteins},
  year={2014},
  volume={82 8},
  pages={1563-82}
}
To assess the state-of-the-art in antibody structure modeling, a blinded study was conducted. Eleven unpublished Fab crystal structures were used as a benchmark to compare Fv models generated by seven structure prediction methodologies. In the first round, each participant submitted three non-ranked complete Fv models for each target. In the second round, CDR-H3 modeling was performed in the context of the correct environment provided by the crystal structures with CDR-H3 removed. In this… CONTINUE READING
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