Antibody-mimicking polymers as chiral stationary phases in HPLC.

  title={Antibody-mimicking polymers as chiral stationary phases in HPLC.},
  author={Maria Kempe},
  journal={Analytical chemistry},
  volume={68 11},
Antibody-mimicking synthetic polymers, selective for various optically active amino acid derivatives and peptides, were prepared by noncovalent molecular imprinting. A novel approach, in which the branched, trifunctional cross-linkers pentaerythritol triacrylate and 2,2-bis(hydroxymethyl)butanol trimethacrylate were copolymerized with methacrylic acid, is described. The polymers were subsequently applied as chiral stationary phases in high-performance liquid chromatography. They were superior… CONTINUE READING