Antibody-mediated retinal pericyte injury: implications for diabetic retinopathy.

  title={Antibody-mediated retinal pericyte injury: implications for diabetic retinopathy.},
  author={Y. Li and D. Smith and Q. Li and N. Sheibani and S. Huang and T. Kern and R. H. Nagaraj and F. Lin},
  journal={Investigative ophthalmology & visual science},
  volume={53 9},
  • Y. Li, D. Smith, +5 authors F. Lin
  • Published 2012
  • Biology, Medicine
  • Investigative ophthalmology & visual science
  • PURPOSE To test the hypothesis that autoantibodies against retinal pericytes could develop in diabetic retinopathy, and that these autoantibodies could induce retinal pericyte dysfunction/death via complement. METHODS Human primary retinal pericytes cultured in media containing normal (5 mM) or high (30 mM) glucose concentrations were incubated with normal human sera in the presence of a retinal pericyte-reactive antibody, then their viability was assessed by a BCECF-based cytotoxicity assay… CONTINUE READING
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