Antibody-mediated retinal pericyte injury: implications for diabetic retinopathy.

@article{Li2012AntibodymediatedRP,
  title={Antibody-mediated retinal pericyte injury: implications for diabetic retinopathy.},
  author={Yan Li and Dawn Smith and Qing Li and Nader Sheibani and Suber S. Huang and Timothy S Kern and Ram H Nagaraj and Feng Lin},
  journal={Investigative ophthalmology & visual science},
  year={2012},
  volume={53 9},
  pages={
          5520-6
        }
}
PURPOSE To test the hypothesis that autoantibodies against retinal pericytes could develop in diabetic retinopathy, and that these autoantibodies could induce retinal pericyte dysfunction/death via complement. METHODS Human primary retinal pericytes cultured in media containing normal (5 mM) or high (30 mM) glucose concentrations were incubated with normal human sera in the presence of a retinal pericyte-reactive antibody, then their viability was assessed by a BCECF-based cytotoxicity assay… CONTINUE READING

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