Antibody-mediated retinal pericyte injury: implications for diabetic retinopathy.
@article{Li2012AntibodymediatedRP, title={Antibody-mediated retinal pericyte injury: implications for diabetic retinopathy.}, author={Y. Li and D. Smith and Q. Li and N. Sheibani and S. Huang and T. Kern and R. H. Nagaraj and F. Lin}, journal={Investigative ophthalmology & visual science}, year={2012}, volume={53 9}, pages={ 5520-6 } }
PURPOSE
To test the hypothesis that autoantibodies against retinal pericytes could develop in diabetic retinopathy, and that these autoantibodies could induce retinal pericyte dysfunction/death via complement.
METHODS
Human primary retinal pericytes cultured in media containing normal (5 mM) or high (30 mM) glucose concentrations were incubated with normal human sera in the presence of a retinal pericyte-reactive antibody, then their viability was assessed by a BCECF-based cytotoxicity assay… CONTINUE READING
25 Citations
Presence of retinal pericyte-reactive autoantibodies in diabetic retinopathy patients
- Medicine
- Scientific reports
- 2016
- 16
- PDF
Pericyte loss in diabetic retinopathy: mechanisms and consequences.
- Medicine
- Current medicinal chemistry
- 2013
- 106
- PDF
Proteasome Activators, PA28α and PA28β, Govern Development of Microvascular Injury in Diabetic Nephropathy and Retinopathy
- Medicine
- International journal of nephrology
- 2016
- 5
- PDF
From Pathobiology to the Targeting of Pericytes for the Treatment of Diabetic Retinopathy
- Medicine
- Current Diabetes Reports
- 2015
- 23
Qualitative and Quantitative Analysis of B-Cell-Produced Antibodies in Vitreous Humor of Type 2 Diabetic Patients with Diabetic Retinopathy
- Medicine
- Journal of diabetes research
- 2020
- PDF
Diabetes-related changes in the protein composition and the biomechanical properties of human retinal vascular basement membranes
- Medicine
- PloS one
- 2017
- 5
- PDF
Role of ω3 polyunsaturated fatty acids in diabetic retinopathy: a morphological and metabolically cross talk among blood retina barriers damage, autoimmunity and chronic inflammation
- Medicine
- Lipids in Health and Disease
- 2019
- 2
Modulation of three key innate immune pathways for the most common retinal degenerative diseases
- Medicine
- EMBO molecular medicine
- 2018
- 36
- PDF
References
SHOWING 1-10 OF 33 REFERENCES
Retinal pericytes inhibit activated T cell proliferation.
- Biology, Medicine
- Investigative ophthalmology & visual science
- 2011
- 57
- PDF
Circulating anti-pericyte autoantibodies are present in Type 2 diabetic patients and are associated with non-proliferative retinopathy
- Medicine
- Diabetologia
- 2003
- 19
- PDF
Early complement activation and decreased levels of glycosylphosphatidylinositol-anchored complement inhibitors in human and experimental diabetic retinopathy.
- Biology, Medicine
- Diabetes
- 2002
- 124
- PDF
Effect of dicarbonyl modification of fibronectin on retinal capillary pericytes.
- Biology, Medicine
- Investigative ophthalmology & visual science
- 2004
- 45
- PDF
Glyoxalase I Is Critical for Human Retinal Capillary Pericyte Survival under Hyperglycemic Conditions*
- Biology, Medicine
- Journal of Biological Chemistry
- 2006
- 96
- PDF
Distribution of TNF alpha and its reactive vascular adhesion molecules in fibrovascular membranes of proliferative diabetic retinopathy.
- Medicine
- The British journal of ophthalmology
- 1996
- 165
- PDF
Effects of protein kinase C inhibition and activation on proliferation and apoptosis of bovine retinal pericytes
- Biology, Medicine
- Diabetologia
- 2003
- 34
- PDF
Advanced glycation end-products induce apoptosis of bovine retinal pericytes in culture: involvement of diacylglycerol/ceramide production and oxidative stress induction.
- Chemistry, Medicine
- Free radical biology & medicine
- 2002
- 129
IL-2 and IFN-gamma in the retina of diabetic rats
- Medicine
- Graefe's Archive for Clinical and Experimental Ophthalmology
- 2009
- 29