Antibody-mediated neutralization of human rhinovirus 14 explored by means of cryoelectron microscopy and X-ray crystallography of virus-Fab complexes.

@article{Che1998AntibodymediatedNO,
  title={Antibody-mediated neutralization of human rhinovirus 14 explored by means of cryoelectron microscopy and X-ray crystallography of virus-Fab complexes.},
  author={Zhiwei Che and Norman H. Olson and Donna M. Leippe and Wai- ming Lee and Anne G. Mosser and Roland R. Rueckert and Timothy S. Baker and Thomas James Smith},
  journal={Journal of virology},
  year={1998},
  volume={72 6},
  pages={4610-22}
}
The structures of three different human rhinovirus 14 (HRV14)-Fab complexes have been explored with X-ray crystallography and cryoelectron microscopy procedures. All three antibodies bind to the NIm-IA site of HRV14, which is the beta-B-beta-C loop of the viral capsid protein VP1. Two antibodies, Fab17-IA (Fab17) and Fab12-IA (Fab12), bind bivalently to the… CONTINUE READING