Antibody-mediated microcirculation injury is the major cause of late kidney transplant failure.

@article{Einecke2009AntibodymediatedMI,
  title={Antibody-mediated microcirculation injury is the major cause of late kidney transplant failure.},
  author={Gunilla Einecke and Banu Sis and J. O. Reeve and Michael 4 Mengel and Patricia M Campbell and Luis G. Hidalgo and Bruce Kaplan and Philip F. Halloran},
  journal={American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons},
  year={2009},
  volume={9 11},
  pages={2520-31}
}
We studied the phenotype of late kidney graft failure in a prospective study of unselected kidney transplant biopsies taken for clinical indications. We analyzed histopathology, HLA antibodies and death-censored graft survival in 234 consecutive biopsies from 173 patients, taken 6 days to 31 years posttransplant. Patients with late biopsies (>1 year) frequently displayed donor-specific HLA antibody (particularly class II) and microcirculation changes, including glomerulitis, glomerulopathy… CONTINUE READING
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