Antibody-mediated enhancement of parvovirus B19 uptake into endothelial cells mediated by a receptor for complement factor C1q.

@article{Kietzell2014AntibodymediatedEO,
  title={Antibody-mediated enhancement of parvovirus B19 uptake into endothelial cells mediated by a receptor for complement factor C1q.},
  author={Kristina von Kietzell and Tanja Pozzuto and Regine Heilbronn and Tobias Gr{\"o}ssl and H. Fechner and Stefan Weger},
  journal={Journal of virology},
  year={2014},
  volume={88 14},
  pages={8102-15}
}
Despite its strong host tropism for erythroid progenitor cells, human parvovirus B19 (B19V) can also infect a variety of additional cell types. Acute and chronic inflammatory cardiomyopathies have been associated with a high prevalence of B19V DNA in endothelial cells of the myocardium. To elucidate the mechanisms of B19V uptake into endothelium, we first analyzed the surface expression of the well-characterized primary B19V receptor P antigen and the putative coreceptors α5β1 integrins and… CONTINUE READING

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Detection of parvovirus B19 DNA in blood: Viruses or DNA remnants?

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology • 2016

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