Antibody-mediated binding of a murine ecotropic Moloney retroviral vector to human cells allows internalization but not the establishment of the proviral state.

@article{Goud1988AntibodymediatedBO,
  title={Antibody-mediated binding of a murine ecotropic Moloney retroviral vector to human cells allows internalization but not the establishment of the proviral state.},
  author={Bruno Goud and Pierre Legrain and G{\'e}rard Buttin},
  journal={Virology},
  year={1988},
  volume={163 1},
  pages={251-4}
}
We have attempted to introduce a neomycin-resistance gene, recombined in a murine (ecotropic) Moloney retrovirus, into HEp2 human cells which are resistant to infection by this retrovirus. To allow the binding of the retroviral vector on HEp2 cells, we have tested several antibody constructions between two monoclonal antibodies, one (mAb 5E9) directed… CONTINUE READING