Antibody-mediated allograft rejection: morphologic spectrum and serologic correlations in surveillance and for cause biopsies.

@article{Papadimitriou2013AntibodymediatedAR,
  title={Antibody-mediated allograft rejection: morphologic spectrum and serologic correlations in surveillance and for cause biopsies.},
  author={John C. Papadimitriou and Cinthia B Drachenberg and Emilio Luis Lucio-Villegas Ramos and Debra L Kukuruga and David K Klassen and R. Urigoitia Ugarte and J. Nogueira and Charles B. Cangro and Matthew R. Weir and Abdolreza Haririan},
  journal={Transplantation},
  year={2013},
  volume={95 1},
  pages={
          128-36
        }
}
BACKGROUND Subclinical antibody-mediated allograft rejection (AMR) has been characterized in serial biopsies from presensitized recipients but has not been systematically studied in conventional renal transplants. METHODS We evaluated 1101 consecutive kidney transplant biopsies (400 surveillance biopsies [SBx] and 701 for cause biopsies [FCBx]) with concurrent donor-specific antibody (DSA) studies, C4d staining, and ultrastructural examination. RESULTS A comparison of AMR-related features… CONTINUE READING
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Rational clinical trial design for antibody mediated renal allograft injury.

  • Frontiers in bioscience
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