Antibody ligation of CM1 on cisplatin-exposed HeLa cells induces apoptosis through reactive oxygen species-dependent Fas ligand expression.

@article{Park2014AntibodyLO,
  title={Antibody ligation of CM1 on cisplatin-exposed HeLa cells induces apoptosis through reactive oxygen species-dependent Fas ligand expression.},
  author={Ga Bin Park and Daejin J Kim and Hoi Soo Yoon and Yang Gon Kim and Hyun-Kyung Lee and Ki Tae Kim and Dae Hoon Jeong and Dae Young Hur},
  journal={International journal of oncology},
  year={2014},
  volume={44 6},
  pages={
          2016-24
        }
}
Centrocyte/centroblast marker 1 (CM1) has been identified as a pro-apoptosis molecule on B-cell lymphoma cells as well as several types of cancer cells. In this study, we investigated its signaling mechanism in HeLa cells after treatment with cisplatin in order to potentially identify a new therapeutic target. The CM1 molecule was induced on the surface of cisplatin-exposed HeLa cells. In these cells, ligation of CM1 with anti-CM1 monoclonal antibodies inhibited cell proliferation and produced… CONTINUE READING

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