Antibody-independent protection against rotavirus infection of mice stimulated by intranasal immunization with chimeric VP4 or VP6 protein.

Abstract

This study was to determine whether individual rotavirus capsid proteins could stimulate protection against rotavirus shedding in an adult mouse model. BALB/c mice were intranasally or intramuscularly administered purified Escherichia coli-expressed murine rotavirus strain EDIM VP4, VP6, or truncated VP7 (TrVP7) protein fused to the 42.7-kDa maltose-binding… (More)

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@article{Choi1999AntibodyindependentPA, title={Antibody-independent protection against rotavirus infection of mice stimulated by intranasal immunization with chimeric VP4 or VP6 protein.}, author={Andrew Choi and M. Basu and Monica M Mcneal and John David Clements and Robyn Lynne Ward}, journal={Journal of virology}, year={1999}, volume={73 9}, pages={7574-81} }