Antibody in middle ear fluid of children originates predominantly from sera and nasopharyngeal secretions.

@article{Kaur2012AntibodyIM,
  title={Antibody in middle ear fluid of children originates predominantly from sera and nasopharyngeal secretions.},
  author={Ravinder Kaur and Thomas C Kim and Janet R. Casey and Michael E. Pichichero},
  journal={Clinical and vaccine immunology : CVI},
  year={2012},
  volume={19 10},
  pages={1593-6}
}
The human middle ear is devoid of any immunocompetent cells in normal mucosa. We sought to determine the source of antibody present in the middle ear of children. Total IgG, IgA, and secretory IgA antibodies were determined by enzyme-linked immunosorbent assay from the nasopharyngeal, middle ear, and serum samples of children with acute otitis media. The… CONTINUE READING