Antibody-guided three-step therapy for high grade glioma with yttrium-90 biotin

  title={Antibody-guided three-step therapy for high grade glioma with yttrium-90 biotin},
  author={Giovanni Paganelli and Chiara Grana and Marco Chinol and Marta Cremonesi and Concetta de Cicco and Filippo G. De Braud and Chris Robertson and Stefano Zurrida and Chiara Casadio and Stefania Zoboli and Antonio G Siccardi and Umberto Veronesi},
  journal={European Journal of Nuclear Medicine},
While the incidence of brain tumours seems to be increasing, median survival in patients with glioblastoma remains less than 1 year, despite improved diagnostic imaging and neurosurgical techniques, and innovations in treatment. We have developed an avidin-biotin pre-targeting approach for delivering therapeutic radionuclides to gliomas, using anti-tenascin monoclonal antibodies, which seems potentially effective for treating these tumours. We treated 48 eligible patients with histologically… CONTINUE READING


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