HIV mRNA Vaccines—Progress and Future Paths
This review discusses mRNA-based approaches for the generation of prophylactic and therapeutic vaccines to HIV, and examines the special immunological hurdles for a vaccine to elicit broadly neutralizing antibodies and effective T cell responses to HIV.
Progress in the Development of Structure-Based Vaccines.
- BiologyMethods in molecular biology
This review states the progress in development of structure-based vaccines since the first review, which concluded that protective epitopes should be sufficient to induce immune responses and provide protection against pathogens.
Peptide-Based Vaccines: Foot-and-Mouth Disease Virus, a Paradigm in Animal Health
The progress towards the development of peptide-based vaccines against foot-and-mouth disease (FMD) a highly transmissible, economically devastating animal disease is reported and the usefulness of this strategy to prevent other animal and human diseases is discussed.
Guiding the Immune Response to a Conserved Epitope in MSP2, an Intrinsically Disordered Malaria Vaccine Candidate
A structure-based approach to peptide vaccine design may be useful not only for MSP2-based malaria vaccines, but also for other intrinsically disordered antigens.
An adjuvanted SARS-CoV-2 RBD nanoparticle elicits neutralizing antibodies and fully protective immunity in aged mice
Overall, CMS:RBD-NP is effective across multiple age groups and is an exemplar of a SARS-CoV-2 subunit vaccine tailored to the elderly.
Sequence-Signature Optimization Enables Improved Identification of Human HV6-1-Derived Class Antibodies That Neutralize Diverse Influenza A Viruses
- BiologyFrontiers in Immunology
An iterative process to combine informatics, biochemical, and structural analyses to delineate an improved sequence signature for HV6-1-class antibodies is used, which can identify class members with increased accuracy.
Structural Biology Illuminates Molecular Determinants of Broad Ebolavirus Neutralization by Human Antibodies for Pan-Ebolavirus Therapeutic Development
- BiologyFrontiers in Immunology
How structural biology has illuminated the molecular basis of broad ebolavirus neutralization is described, including details of common antigenic sites of vulnerability on the glycoprotein surface, as well as key structural studies that have advanced understanding of ebolvirus glycop protein structures and mechanisms of antibody-mediated neutralization.
A multiclade env-gag VLP mRNA vaccine elicits tier-2 HIV-1-neutralizing antibodies and reduces the risk of heterologous SHIV infection in macaques.
- BiologyNature medicine
The multiclade env-gag VLP mRNA platform represents a promising approach for the development of an HIV-1 vaccine and induces antibodies capable of broad neutralization and reduces the risk of infection in rhesus macaques.
Affinity Tag Coating Enables Reliable Detection of Antigen-Specific B Cells in Immunospot Assays
Establishment of a universal antigen-coating approach streamlines characterization of the memory B-cell compartment after SARS-CoV-2 infection or COVID-19 vaccinations, and facilitates high-throughput immune-monitoring efforts of large donor cohorts in general.
Affinity tag coating enables reliable detection of antigen-specific B cells in ImmunoSpot assays
Establishment of a universal antigen coating approach streamlines characterization of the memory B cell compartment after SARS-CoV-2 infection or COVID-19 vaccinations, and facilitates high-throughput immune monitoring efforts of large donor cohorts in general.
SHOWING 1-10 OF 197 REFERENCES
Nanoparticles in influenza subunit vaccine development: Immunogenicity enhancement
- BiologyInfluenza and other respiratory viruses
This review will discuss on the applications, advantages, limitations, and types of nanoparticles used in the preparation of influenza subunit vaccine candidates to enhance humoral and cellular immune responses.
Proof of principle for epitope-focused vaccine design
It is shown, with a neutralization epitope from respiratory syncytial virus, that computational protein design can generate small, thermally and conformationally stable protein scaffolds that accurately mimic the viral epitope structure and induce potent neutralizing antibodies.
HIV-1 Vaccines Based on Antibody Identification, B Cell Ontogeny, and Epitope Structure.
A generalized HIV vaccine design strategy for priming of broadly neutralizing antibody responses
Among several new vaccine strategies, germline-targeting vaccine design aims to induce bnAbs by first stimulating bnAb-precursor B cells and then shepherding B cell affinity maturation with a series of rationally designed boosting immunogens.
A proof of concept for structure-based vaccine design targeting RSV in humans
Building a better RSV vaccine Respiratory syncytial virus (RSV) causes severe respiratory disease, especially in infants and the elderly. However, attempts to produce effective human vaccines have…
Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1
- BiologyNature Medicine
It is shown that focusing the immune response to exposed N-terminal residues of the fusion peptide, a critical component of the viral entry machinery and the epitope of antibodies elicited by HIV-1 infection, through immunization with fusion peptIDE-coupled carriers and prefusion stabilized envelope trimers, induces cross-clade neutralizing responses.
How advances in immunology provide insight into improving vaccine efficacy.
- Biology, MedicineVaccine
Iterative structure-based improvement of a fusion-glycoprotein vaccine against RSV
- BiologyNature Structural &Molecular Biology
The resultant second-generation 'DS2'-stabilized immunogens have their F subunits genetically linked, their fusion peptides deleted and their interprotomer movements stabilized by an additional disulfide bond and may have utility in the optimization of other vaccine antigens.
Boosting subdominant neutralizing antibody responses with a computationally designed epitope-focused immunogen
- BiologyPLoS biology
It is shown that epitope-focused immunogens can boost subdominant neutralizing antibody responses in vivo and reshape established antibody hierarchies.
De novo protein design enables the precise induction of RSV-neutralizing antibodies
This work proposes a strategy to assemble protein topologies tailored to the functional motif with the ultimate aim of enabling the design of de novo proteins endowed with complex structural motifs, and presents a blueprint for epitope-centric vaccine design.