Antibody-guided structure-based vaccines.

@article{Kwong2020AntibodyguidedSV,
  title={Antibody-guided structure-based vaccines.},
  author={Peter D. Kwong and Brandon J Dekosky and Jeffrey B. Ulmer},
  journal={Seminars in immunology},
  year={2020},
  pages={
          101428
        }
}
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17 Citations
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17 Citations

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HIV mRNA Vaccines—Progress and Future Paths
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This review discusses mRNA-based approaches for the generation of prophylactic and therapeutic vaccines to HIV, and examines the special immunological hurdles for a vaccine to elicit broadly neutralizing antibodies and effective T cell responses to HIV.
Progress in the Development of Structure-Based Vaccines.
TLDR
This review states the progress in development of structure-based vaccines since the first review, which concluded that protective epitopes should be sufficient to induce immune responses and provide protection against pathogens.
Peptide-Based Vaccines: Foot-and-Mouth Disease Virus, a Paradigm in Animal Health
TLDR
The progress towards the development of peptide-based vaccines against foot-and-mouth disease (FMD) a highly transmissible, economically devastating animal disease is reported and the usefulness of this strategy to prevent other animal and human diseases is discussed.
Guiding the Immune Response to a Conserved Epitope in MSP2, an Intrinsically Disordered Malaria Vaccine Candidate
TLDR
A structure-based approach to peptide vaccine design may be useful not only for MSP2-based malaria vaccines, but also for other intrinsically disordered antigens.
An adjuvanted SARS-CoV-2 RBD nanoparticle elicits neutralizing antibodies and fully protective immunity in aged mice
TLDR
Overall, CMS:RBD-NP is effective across multiple age groups and is an exemplar of a SARS-CoV-2 subunit vaccine tailored to the elderly.
Sequence-Signature Optimization Enables Improved Identification of Human HV6-1-Derived Class Antibodies That Neutralize Diverse Influenza A Viruses
TLDR
An iterative process to combine informatics, biochemical, and structural analyses to delineate an improved sequence signature for HV6-1-class antibodies is used, which can identify class members with increased accuracy.
Structural Biology Illuminates Molecular Determinants of Broad Ebolavirus Neutralization by Human Antibodies for Pan-Ebolavirus Therapeutic Development
TLDR
How structural biology has illuminated the molecular basis of broad ebolavirus neutralization is described, including details of common antigenic sites of vulnerability on the glycoprotein surface, as well as key structural studies that have advanced understanding of ebolvirus glycop protein structures and mechanisms of antibody-mediated neutralization.
A multiclade env-gag VLP mRNA vaccine elicits tier-2 HIV-1-neutralizing antibodies and reduces the risk of heterologous SHIV infection in macaques.
TLDR
The multiclade env-gag VLP mRNA platform represents a promising approach for the development of an HIV-1 vaccine and induces antibodies capable of broad neutralization and reduces the risk of infection in rhesus macaques.
Affinity Tag Coating Enables Reliable Detection of Antigen-Specific B Cells in Immunospot Assays
TLDR
Establishment of a universal antigen-coating approach streamlines characterization of the memory B-cell compartment after SARS-CoV-2 infection or COVID-19 vaccinations, and facilitates high-throughput immune-monitoring efforts of large donor cohorts in general.
Affinity tag coating enables reliable detection of antigen-specific B cells in ImmunoSpot assays
TLDR
Establishment of a universal antigen coating approach streamlines characterization of the memory B cell compartment after SARS-CoV-2 infection or COVID-19 vaccinations, and facilitates high-throughput immune monitoring efforts of large donor cohorts in general.
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