Antibody-guided structure-based vaccines.

@article{Kwong2020AntibodyguidedSV,
  title={Antibody-guided structure-based vaccines.},
  author={Peter D. Kwong and Brandon J Dekosky and Jeffrey B. Ulmer},
  journal={Seminars in immunology},
  year={2020},
  pages={
          101428
        }
}
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15 Citations
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15 Citations

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HIV mRNA Vaccines—Progress and Future Paths
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This review discusses mRNA-based approaches for the generation of prophylactic and therapeutic vaccines to HIV, and examines the special immunological hurdles for a vaccine to elicit broadly neutralizing antibodies and effective T cell responses to HIV.
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This review states the progress in development of structure-based vaccines since the first review, which concluded that protective epitopes should be sufficient to induce immune responses and provide protection against pathogens.
Peptide-Based Vaccines: Foot-and-Mouth Disease Virus, a Paradigm in Animal Health
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The progress towards the development of peptide-based vaccines against foot-and-mouth disease (FMD) a highly transmissible, economically devastating animal disease is reported and the usefulness of this strategy to prevent other animal and human diseases is discussed.
Guiding the Immune Response to a Conserved Epitope in MSP2, an Intrinsically Disordered Malaria Vaccine Candidate
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A structure-based approach to peptide vaccine design may be useful not only for MSP2-based malaria vaccines, but also for other intrinsically disordered antigens.
An adjuvanted SARS-CoV-2 RBD nanoparticle elicits neutralizing antibodies and fully protective immunity in aged mice
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Overall, CMS:RBD-NP is effective across multiple age groups and is an exemplar of a SARS-CoV-2 subunit vaccine tailored to the elderly.
Sequence-Signature Optimization Enables Improved Identification of Human HV6-1-Derived Class Antibodies That Neutralize Diverse Influenza A Viruses
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An iterative process to combine informatics, biochemical, and structural analyses to delineate an improved sequence signature for HV6-1-class antibodies is used, which can identify class members with increased accuracy.
Structural Biology Illuminates Molecular Determinants of Broad Ebolavirus Neutralization by Human Antibodies for Pan-Ebolavirus Therapeutic Development
Monoclonal antibodies (mAbs) have proven effective for the treatment of ebolavirus infection in humans, with two mAb-based drugs Inmazeb™ and Ebanga™ receiving FDA approval in 2020. While these drugs…
A multiclade env-gag VLP mRNA vaccine elicits tier-2 HIV-1-neutralizing antibodies and reduces the risk of heterologous SHIV infection in macaques.
TLDR
The multiclade env-gag VLP mRNA platform represents a promising approach for the development of an HIV-1 vaccine and induces antibodies capable of broad neutralization and reduces the risk of infection in rhesus macaques.
Affinity Tag Coating Enables Reliable Detection of Antigen-Specific B Cells in Immunospot Assays
TLDR
Establishment of a universal antigen-coating approach streamlines characterization of the memory B-cell compartment after SARS-CoV-2 infection or COVID-19 vaccinations, and facilitates high-throughput immune-monitoring efforts of large donor cohorts in general.
Affinity tag coating enables reliable detection of antigen-specific B cells in ImmunoSpot assays
TLDR
Establishment of a universal antigen coating approach streamlines characterization of the memory B cell compartment after SARS-CoV-2 infection or COVID-19 vaccinations, and facilitates high-throughput immune monitoring efforts of large donor cohorts in general.
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