Antibody-guided structure-based vaccines.

@article{Kwong2020AntibodyguidedSV,
  title={Antibody-guided structure-based vaccines.},
  author={Peter D. Kwong and Brandon J Dekosky and Jeffrey B. Ulmer},
  journal={Seminars in immunology},
  year={2020},
  pages={
          101428
        }
}
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References

SHOWING 1-10 OF 197 REFERENCES
Nanoparticles in influenza subunit vaccine development: Immunogenicity enhancement
TLDR
This review will discuss on the applications, advantages, limitations, and types of nanoparticles used in the preparation of influenza subunit vaccine candidates to enhance humoral and cellular immune responses.
Proof of principle for epitope-focused vaccine design
TLDR
It is shown, with a neutralization epitope from respiratory syncytial virus, that computational protein design can generate small, thermally and conformationally stable protein scaffolds that accurately mimic the viral epitope structure and induce potent neutralizing antibodies.
A generalized HIV vaccine design strategy for priming of broadly neutralizing antibody responses
TLDR
Among several new vaccine strategies, germline-targeting vaccine design aims to induce bnAbs by first stimulating bnAb-precursor B cells and then shepherding B cell affinity maturation with a series of rationally designed boosting immunogens.
A proof of concept for structure-based vaccine design targeting RSV in humans
Building a better RSV vaccine Respiratory syncytial virus (RSV) causes severe respiratory disease, especially in infants and the elderly. However, attempts to produce effective human vaccines have
Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1
TLDR
It is shown that focusing the immune response to exposed N-terminal residues of the fusion peptide, a critical component of the viral entry machinery and the epitope of antibodies elicited by HIV-1 infection, through immunization with fusion peptIDE-coupled carriers and prefusion stabilized envelope trimers, induces cross-clade neutralizing responses.
Iterative structure-based improvement of a fusion-glycoprotein vaccine against RSV
TLDR
The resultant second-generation 'DS2'-stabilized immunogens have their F subunits genetically linked, their fusion peptides deleted and their interprotomer movements stabilized by an additional disulfide bond and may have utility in the optimization of other vaccine antigens.
Boosting subdominant neutralizing antibody responses with a computationally designed epitope-focused immunogen
TLDR
It is shown that epitope-focused immunogens can boost subdominant neutralizing antibody responses in vivo and reshape established antibody hierarchies.
De novo protein design enables the precise induction of RSV-neutralizing antibodies
TLDR
This work proposes a strategy to assemble protein topologies tailored to the functional motif with the ultimate aim of enabling the design of de novo proteins endowed with complex structural motifs, and presents a blueprint for epitope-centric vaccine design.
...
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2
3
4
5
...