Antibody-guided irradiation of advanced ovarian cancer with intraperitoneally administered radiolabeled monoclonal antibodies.

@article{Epenetos1987AntibodyguidedIO,
  title={Antibody-guided irradiation of advanced ovarian cancer with intraperitoneally administered radiolabeled monoclonal antibodies.},
  author={Agamemnon A. Epenetos and Alastair J. Munro and Shelby Stewart and Roy Rampling and Herv{\'e} Lambert and Carey McKenzie and Pat Soutter and Amir Rahemtulla and G. R. Hooker and Gregory B. Sivolapenko},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={1987},
  volume={5 12},
  pages={
          1890-9
        }
}
Twenty-four patients with persistent epithelial ovarian cancer after chemotherapy with or without external beam irradiation, were treated with intraperitoneally administered 131I-labeled monoclonal antibodies HMFG1, HMFG2, AUA1, H17E2, directed against tumor-associated antigens. Acute side effects were mild abdominal pain, pyrexia, diarrhea, and moderate reversible pancytopenia. One patient developed a subphrenic abscess requiring surgical drainage. Eight patients with large volume disease, ie… CONTINUE READING
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