Antibody from mice immunized with DNA encoding the carboxyl-disintegrin and cysteine-rich domain (JD9) of the haemorrhagic metalloprotease, Jararhagin, inhibits the main lethal component of viper venom.

@article{Harrison2000AntibodyFM,
  title={Antibody from mice immunized with DNA encoding the carboxyl-disintegrin and cysteine-rich domain (JD9) of the haemorrhagic metalloprotease, Jararhagin, inhibits the main lethal component of viper venom.},
  author={Robert A. Harrison and Ana Maria Moura-da-Silva and G Laing and Y Wu and Allan Richards and Alex R Broadhead and Albert Edward Bianco and Robert David Geoffrey Theakston},
  journal={Clinical and experimental immunology},
  year={2000},
  volume={121 2},
  pages={358-63}
}
Envenoming by the Brazilian pit viper, Bothrops jararaca, induces extensive local and systemic haemorrhage in humans. The severe and occasionally lethal outcome of envenoming is prevented only by administration of antivenom which is conventionally prepared by hyperimmunization of large animals with an individual venom or a range of venoms. Since snake venoms typically consist of numerous molecules, only some of which are toxic, antivenoms are antigenically crude preparations whose therapeutic… CONTINUE READING

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