Antibody-forming potential of lymph nodes in aged mice, with special reference to the influence of adjuvant.

@article{Finger1977AntibodyformingPO,
  title={Antibody-forming potential of lymph nodes in aged mice, with special reference to the influence of adjuvant.},
  author={Horst Finger and Berno Heymer and Prof. Dr. med. P. Emmerling and Herbert Hof},
  journal={Gerontology},
  year={1977},
  volume={23 3},
  pages={185-204}
}
The secondary antibody-forming potential of non-splenic lymphatic tissues during senescence was investigated in NMRI/Han mice, both at the cellular and humoral levels. The mean life span of conventionally reared NMRI/Han mice amounts to 19.86 months. After primary immunization of aged (20-month-old) NMRI mice with 4 X 10(8) sheep erythrocytes (SE) by the intraperitoneal (i.p.) route, the primary antibody-forming potential of both spleen and lymph nodes was significantly reduced, as compared to… CONTINUE READING