Antibody-fluorescein conjugates for photoimmunodiagnosis of human colon carcinoma in nude mice.

Abstract

To improve the detectability of tumors by light-induced fluorescence, the use of monoclonal antibodies (MoAb) as carriers of fluorescent molecules was studied. As a model for this approach, the biodistribution of an anticarcinoembryonic antigen (CEA) MoAb coupled to fluorescein was studied in mice bearing a human colon carcinoma xenograft. In vitro, such… (More)

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Cite this paper

@article{Pelegrin1991AntibodyfluoresceinCF, title={Antibody-fluorescein conjugates for photoimmunodiagnosis of human colon carcinoma in nude mice.}, author={Andr{\'e} Pelegrin and S{\'e}rgio Folli and Franz Buchegger and J. P. Mach and Georges Wagni{\`e}res and Hubert E van den Bergh}, journal={Cancer}, year={1991}, volume={67 10}, pages={2529-37} }