Antibody-directed myostatin inhibition enhances muscle mass and function in tumor-bearing mice.

@article{Murphy2011AntibodydirectedMI,
  title={Antibody-directed myostatin inhibition enhances muscle mass and function in tumor-bearing mice.},
  author={Kate T. Murphy and Annabel Y. -M. Chee and Ben G Gleeson and Timur Naim and Kristy Swiderski and Ren{\'e} Koopman and Gordon S Lynch},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2011},
  volume={301 3},
  pages={R716-26}
}
Cancer cachexia describes the progressive skeletal muscle wasting and weakness in many cancer patients and accounts for >20% of cancer-related deaths. We tested the hypothesis that antibody-directed myostatin inhibition would attenuate the atrophy and loss of function in muscles of tumor-bearing mice. Twelve-week-old C57BL/6 mice received a subcutaneous injection of saline (control) or Lewis lung carcinoma (LLC) tumor cells. One week later, mice received either once weekly injections of saline… CONTINUE READING

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Injection of LLC cells reduced muscle mass and maximum force of tibialis anterior ( TA ) muscles by 8 - 10% ( P < 0.05 ) , but the muscle atrophy and weakness were prevented with PF-354 treatment ( P > 0.05 ) .
Injection of LLC cells reduced muscle mass and maximum force of tibialis anterior ( TA ) muscles by 8 - 10% ( P < 0.05 ) , but the muscle atrophy and weakness were prevented with PF-354 treatment ( P > 0.05 ) .
Twelve - week - old C57BL/6 mice received a subcutaneous injection of saline ( control ) or Lewis lung carcinoma ( LLC ) tumor cells .
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