Antibody-dependent enhancement (ADE) of porcine reproductive and respiratory syndrome virus (PRRSV) infection in pigs.

@article{Yoon1996AntibodydependentE,
  title={Antibody-dependent enhancement (ADE) of porcine reproductive and respiratory syndrome virus (PRRSV) infection in pigs.},
  author={K j Yoon and Lily L. Wu and Jeffrey Zimmerman and Howard T. Hill and Kenneth B. Platt},
  journal={Viral immunology},
  year={1996},
  volume={9 1},
  pages={51-63}
}
Infection of porcine alveolar macrophages by the porcine reproductive and respiratory syndrome virus (PRRSV) was significantly enhanced in vitro by antibody raised against the PRRSV isolate ISU-P (p < 0.01). Increased yields and infection rates were highly correlated (r = 0.95) and the ratio of yield to infection rate was greater than 1.4, suggesting that more than one mechanism was responsible for enhanced infection. Antibody-dependent enhancement (ADE) of infection was also demonstrated in… CONTINUE READING