Antibody-dependent complement-mediated cytotoxicity in sera from patients with HIV-1 infection is controlled by CD55 and CD59.

@article{Schmitz1995AntibodydependentCC,
  title={Antibody-dependent complement-mediated cytotoxicity in sera from patients with HIV-1 infection is controlled by CD55 and CD59.},
  author={Juergen Schmitz and J. Pascal Zimmer and B Kluxen and S. P. Aries and Mark M. Boegel and I Giovanni Gigli and Herbert Schmitz},
  journal={The Journal of clinical investigation},
  year={1995},
  volume={96 3},
  pages={1520-6}
}
Various immune mechanisms have been reported to contribute to the progressive destruction of Th cells in HIV-1-infected patients. Among these, complement mediated lysis of infected cells has been suggested. An increased sensitivity of lymphocytes from HIV-1-infected patients to lysis by monoclonal antibodies directed to MHC class I antigen and complement has been directly correlated with a decreased expression of the decay accelerating factor (CD55). It also has been reported that the… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 26 extracted citations

Similar Papers

Loading similar papers…