Antibody-dependent cellular cytotoxicity via humoral immune epitope of Nef protein expressed on cell surface.

@article{Yamada2004AntibodydependentCC,
  title={Antibody-dependent cellular cytotoxicity via humoral immune epitope of Nef protein expressed on cell surface.},
  author={Takeshi Yamada and Nobukazu Watanabe and Tetsuya Nakamura and Aikichi Iwamoto},
  journal={Journal of immunology},
  year={2004},
  volume={172 4},
  pages={2401-6}
}
Antibodies against various proteins of HIV type 1 (HIV-1) can be detected in HIV-1-infected individuals. We previously reported that the level of Ab response against one Nef epitope is correlated with HIV-1 disease progression. To elucidate the mechanism for this correlation, we examined Ab-dependent cellular cytotoxicity (ADCC) against target cells expressing Nef. We observed efficient cytotoxicity against Nef-expressing target cells in the presence of patient plasma and PBMCs. This ADCC… CONTINUE READING