Antibody-dependent cellular cytotoxicity is directed against both the gp120 and gp41 envelope proteins of HIV.

@article{Evans1989AntibodydependentCC,
  title={Antibody-dependent cellular cytotoxicity is directed against both the gp120 and gp41 envelope proteins of HIV.},
  author={L. A. R. Evans and G A Thomson-Honnebier and Kathelyn S. Steimer and Enzo Paoletti and Marion E. Perkus and Harry Hollander and Jay A. Levy},
  journal={AIDS},
  year={1989},
  volume={3 5},
  pages={273-6}
}
To define the target antigens for antibody-dependent cellular cytotoxicity (ADCC), assays were performed using affinity-purified human immunoglobulin (Ig) or polyclonal rabbit sera directed against specific proteins of HIV. ADCC was not found using affinity-purified anti-core (p25) human Ig or sera obtained from rabbits hyper-immunized with recombinant p25. However, when affinity-purified human Ig or rabbit antisera specific for the envelope glycoproteins, gp120 or gp41, were used in ADCC… CONTINUE READING

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