Antibody-dependent cellular cytotoxicity (ADCC) is mediated by genetically modified antigen-specific human T lymphocytes.

@article{Clmenceau2006AntibodydependentCC,
  title={Antibody-dependent cellular cytotoxicity (ADCC) is mediated by genetically modified antigen-specific human T lymphocytes.},
  author={B{\'e}atrice Cl{\'e}menceau and Nicolas Congy-Jolivet and G{\'e}raldine Gallot and R{\'e}gine Vivien and Jo{\"e}lle Gaschet and Gilles Thibault and Henri Vi{\'e}},
  journal={Blood},
  year={2006},
  volume={107 12},
  pages={4669-77}
}
In the context of transplantation, donor and virus-specific T-lymphocyte infusions have demonstrated the dramatic potential of T cells as immune effectors. Unfortunately, most attempts to exploit the T-cell immune system against nonviral malignancies in the syngeneic setting have been disappointing. In contrast, treatments based on monoclonal antibodies (Abs) have been clinically successful and have demonstrated the clinical relevance of several antigens as therapeutic targets and the… CONTINUE READING

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