Antibody-dependent SARS coronavirus infection is mediated by antibodies against spike proteins.

@article{Wang2014AntibodydependentSC,
  title={Antibody-dependent SARS coronavirus infection is mediated by antibodies against spike proteins.},
  author={Sheng-Fan Wang and S P Tseng and Chia-Hung Yen and J Y Yang and Ching-Han Tsao and Chun-Wei Shen and Kuan-Hsuan Chen and Fu-tong Liu and W T Liu and Yi-Ming Arthur Chen and Jason C. Huang},
  journal={Biochemical and biophysical research communications},
  year={2014},
  volume={451 2},
  pages={208-14}
}
The severe acute respiratory syndrome coronavirus (SARS-CoV) still carries the potential for reemergence, therefore efforts are being made to create a vaccine as a prophylactic strategy for control and prevention. Antibody-dependent enhancement (ADE) is a mechanism through which dengue viruses, feline coronaviruses, and HIV viruses take advantage of anti-viral humoral immune responses to infect host target cells. Here we describe our observations of SARS-CoV using ADE to enhance the infectivity… CONTINUE READING
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