Antibody-conjugated nanoparticles for therapeutic applications.

@article{Cardoso2012AntibodyconjugatedNF,
  title={Antibody-conjugated nanoparticles for therapeutic applications.},
  author={M Margarida Cardoso and In{\^e}s N. Peça and Ana Cec{\'i}lia Afonso Roque},
  journal={Current medicinal chemistry},
  year={2012},
  volume={19 19},
  pages={
          3103-27
        }
}
A great challenge to clinical development is the delivery of chemotherapeutic agents, known to cause severe toxic effects, directly to diseased sites which increase the therapeutic index whilst minimizing off-target side effects. Antibody-conjugated nanoparticles offer great opportunities to overcome these limitations in therapeutics. They combine the advantages given by the nanoparticles with the ability to bind to their target with high affinity and improve cell penetration given by the… 

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