Antibody class and subclass responses to pneumococcal polysaccharides following immunization of human immunodeficiency virus-infected patients.

@article{Carson1995AntibodyCA,
  title={Antibody class and subclass responses to pneumococcal polysaccharides following immunization of human immunodeficiency virus-infected patients.},
  author={Paul J. Carson and Ronald Schut and Mary L. Simpson and Joseph D. O'Brien and Edward N. Janoff},
  journal={The Journal of infectious diseases},
  year={1995},
  volume={172 2},
  pages={
          340-5
        }
}
Antibodies of the IgM class and IgG2 and IgA2 subclasses are prominent in responses to pneumococcal polysaccharides (PPS) but may be decreased in human immunodeficiency virus (HIV)-infected patients, among whom invasive pneumococcal disease is common. After immunization of HIV-infected and -seronegative subjects with pneumococcal vaccine, the number of PPS-specific antibody-secreting cells (ASC) producing IgM was significantly lower among HIV-infected subjects, whereas PPS-specific IgG and IgA… CONTINUE READING
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