Antibody-bound amyloid precursor protein upregulates ornithine decarboxylase expression.

  title={Antibody-bound amyloid precursor protein upregulates ornithine decarboxylase expression.},
  author={Tatjana Nilsson and Katarzyna Malkiewicz and Maria Gabrielsson and Ronnie Folkesson and Bengt Winblad and Eir{\'i}kur Benedikz},
  journal={Biochemical and biophysical research communications},
  volume={341 4},
Alzheimer's disease is a neurodegenerative disorder characterised by extracellular accumulation of the Abeta peptide, derived from the amyloid precursor protein (APP). The function of APP as a cell surface receptor was examined by ligand-mimicking using an antibody against the APP extracellular domain. Alterations in gene expression evoked by antibody-bound APP were analysed using human pathway-finder gene arrays and the largest change in expression levels was found for ornithine decarboxylase… CONTINUE READING

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