Antibody blockade of the Cripto CFC domain suppresses tumor cell growth in vivo.

  title={Antibody blockade of the Cripto CFC domain suppresses tumor cell growth in vivo.},
  author={Heather B. Adkins and C. Bianco and S. Schiffer and P. Rayhorn and M. Zafari and Anne E Cheung and O. Orozco and D. Olson and A. de Luca and L. L. Chen and K. Miatkowski and C. Benjamin and N. Normanno and K. Williams and Matthew B. Jarpe and D. Lepage and D. Salom{\'o}n and M. Sanicola},
  journal={The Journal of clinical investigation},
  volume={112 4},
  • Heather B. Adkins, C. Bianco, +15 authors M. Sanicola
  • Published 2003
  • Biology, Medicine
  • The Journal of clinical investigation
  • Cripto, a cell surface-associated protein belonging to the EGF-CFC family of growth factor-like molecules, is overexpressed in many human solid tumors, including 70-80% of breast and colon tumors, yet how it promotes cell transformation is unclear. During embryogenesis, Cripto complexes with Alk4 via its unique cysteine-rich CFC domain to facilitate signaling by the TGF-beta ligand Nodal. We report, for the first time to our knowledge, that Cripto can directly bind to another TGF-beta ligand… CONTINUE READING
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