Antibody blockade of junctional adhesion molecule-A in rabbit corneal endothelial tight junctions produces corneal swelling.

@article{Mandell2006AntibodyBO,
  title={Antibody blockade of junctional adhesion molecule-A in rabbit corneal endothelial tight junctions produces corneal swelling.},
  author={Kenneth J. Mandell and Glenn P. Holley and Charles A Parkos and Henry F. Francis Edelhauser},
  journal={Investigative ophthalmology & visual science},
  year={2006},
  volume={47 6},
  pages={2408-16}
}
PURPOSE The ultrastructure of tight junctions in the corneal endothelium has been studied extensively, yet little is known about their molecular composition. Junctional adhesion molecule-A (JAM-A) is a tight junction-associated adhesion protein previously implicated in tight junction assembly and regulation of barrier function. In this study, we sought to investigate the expression and function of JAM-A in the corneal endothelium. METHODS Immunofluorescence confocal microscopy was used to… CONTINUE READING