Antibody blockade of c-fms suppresses the progression of inflammation and injury in early diabetic nephropathy in obese db/db mice

@article{Lim2009AntibodyBO,
  title={Antibody blockade of c-fms suppresses the progression of inflammation and injury in early diabetic nephropathy in obese db/db mice},
  author={Andy Lim and F. Yanhua Ma and David J Nikolic-Paterson and Merlin C Thomas and Lynette A Hurst and Greg H. Tesch},
  journal={Diabetologia},
  year={2009},
  volume={52},
  pages={1669-1679}
}
Macrophage-mediated renal injury plays an important role in the development of diabetic nephropathy. Colony-stimulating factor (CSF)-1 is a cytokine that is produced in diabetic kidneys and promotes macrophage accumulation, activation and survival. CSF-1 acts exclusively through the c-fms receptor, which is only expressed on cells of the monocyte–macrophage lineage. Therefore, we used c-fms blockade as a strategy to selectively target macrophage-mediated injury during the progression of… CONTINUE READING
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