Antibody-based detection of ERG rearrangement-positive prostate cancer.

  title={Antibody-based detection of ERG rearrangement-positive prostate cancer.},
  author={Kyung Ja Park and Scott Arthur Tomlins and Kumaran M. Mudaliar and Ya-lin Chiu and Raquel Esgueva and Rohit Mehra and Khalid Suleman and Sooryanarayana Varambally and J. Chad Brenner and Theresa Macdonald and Abhishek K. Srivastava and Ashutosh Tewari and Ubaradka G Sathyanarayana and Dea Nagy and Gary A. Pestano and Lakshmi Priya Kunju and Francesca Demichelis and Arul M. Chinnaiyan and Mark A. Rubin},
  volume={12 7},
TMPRSS2-ERG gene fusions occur in 50% of prostate cancers and result in the overexpression of a chimeric fusion transcript that encodes a truncated ERG product. Previous attempts to detect truncated ERG products have been hindered by a lack of specific antibodies. Here, we characterize a rabbit anti-ERG monoclonal antibody (clone EPR 3864; Epitomics, Burlingame, CA) using immunoblot analysis on prostate cancer cell lines, synthetic TMPRSS2-ERG constructs, chromatin immunoprecipitation, and… CONTINUE READING
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