Antibody and cellular immune responses of swine following immunisation with plasmid DNA encoding the PRRS virus ORF's 4, 5, 6 and 7.

@article{Kwang1999AntibodyAC,
  title={Antibody and cellular immune responses of swine following immunisation with plasmid DNA encoding the PRRS virus ORF's 4, 5, 6 and 7.},
  author={Jimmy Kwang and Federico A. Zuckermann and Gordon Ross and Suzhen Yang and Fernando G. Osorio and Weihong Liu and Sharon Low},
  journal={Research in veterinary science},
  year={1999},
  volume={67 2},
  pages={199-201}
}
The objectives of this study was to investigate the role of DNA vaccines in the generation of an immune response and that elicited against individually encoded proteins of PRRSV. The genomic regions encoding ORF s 4, 5, 6 and 7 of the PRRS virus vaccine strain were cloned into the mammalian expression vector pc DNA 3.1 (+). Inoculations with the recombinant plasmids resulted in detection of PRRS virus-specific antibodies in 71 per cent of the immunized animals by ELISA, virus neutralization and… CONTINUE READING
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