Antibody against murine PECAM-1 inhibits tumor angiogenesis in mice

  title={Antibody against murine PECAM-1 inhibits tumor angiogenesis in mice},
  author={Zhao Pin Zhou and Melpo Christofidou-Solomidou and Cecilia Garlanda and Horace M. Delisser},
Platelet endothelial cell adhesion molecule (PECAM-1/CD31), a member of the immunoglobulin superfamily expressed at high levels on endothelial cells, has been recently implicated in angiogenesis. Although antagonism of PECAM-1 inhibited neovascularization in two different animal models of growth factor/chemokine-induced angiogenesis, its participation in tumor angiogenesis has not been established. We therefore investigated its involvement in models of tumor angiogenesis in mice. An antibody… CONTINUE READING


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The biology of PECAM-1

  • PJ Newman
  • J Clin Invest
  • 1997
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