Antibody Responses to Antigenic Determinants of Influenza Virus Hemagglutinin

  title={Antibody Responses to Antigenic Determinants of Influenza Virus Hemagglutinin},
  author={Jean Louis Virelizier and Anthony C. Allison and Geoffrey C. Schild},
  journal={The Journal of Experimental Medicine},
  pages={1571 - 1578}
Mice immunized sequentially with two related influenza virus hemagglutinins (HA) produced a secondary antibody response with two different specificities. Some antibodies were specific for determinants common to both HA's. Paradoxically, some antibodies were directed to determinants existing only in the HA first encountered. Primed spleen cells treated with anti-theta serum and complement were transferred from animals immunized with the first HA to either normal, irradiated, or thymus-deprived… CONTINUE READING


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