Antibody-Mediated Targeting of Tau In Vivo Does Not Require Effector Function and Microglial Engagement.

  title={Antibody-Mediated Targeting of Tau In Vivo Does Not Require Effector Function and Microglial Engagement.},
  author={Seung-Hye Lee and Claire E Le Pichon and Oskar Adolfsson and Val{\'e}rie Gafner and Maria Pihlgren and Han Lin and Hilda O. Solanoy and Robert Brendza and Hai Ngu and Oded Foreman and Ruby Chan and James A. Ernst and Danielle Dicara and Isidro Hotzel and Karpagam Srinivasan and David V Hansen and Jasvinder Atwal and Yanmei Lu and Daniela Bumbaca and A. Kl{\'a}ra Pfeifer and Ryan J. Watts and Andreas Muhs and Kimberly A Scearce-Levie and Gai Ayalon},
  journal={Cell reports},
  volume={16 6},
The spread of tau pathology correlates with cognitive decline in Alzheimer's disease. In vitro, tau antibodies can block cell-to-cell tau spreading. Although mechanisms of anti-tau function in vivo are unknown, effector function might promote microglia-mediated clearance. In this study, we investigated whether antibody effector function is required for targeting tau. We compared efficacy in vivo and in vitro of two versions of the same tau antibody, with and without effector function, measuring… CONTINUE READING
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Antibody-Mediated Targeting of Tau In Vivo Does Not Require Effector Function and Microglial Engagement

  • Lee
  • Cell Reports (2016),
  • 2016

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