Antibody-Mediated Encephalitis.

@article{Dalmau2018AntibodyMediatedE,
  title={Antibody-Mediated Encephalitis.},
  author={Josep Dalmau and Francesc Graus},
  journal={The New England journal of medicine},
  year={2018},
  volume={378 9},
  pages={
          840-851
        }
}
  • J. Dalmau, F. Graus
  • Published 28 February 2018
  • Medicine
  • The New England journal of medicine
Antibody-Mediated Encephalitis The category of autoimmune encephalitides constitutes disorders with relatively distinct characteristics such as psychosis, seizures, abnormal movements, coma, and dysautonomia. Specific autoantibodies can be identified, and the disorders can be successfully treated. 
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TLDR
This work aimed to analyze the intrathecal plasma cell repertoire, identify autoantibody‐producing clones, and characterize their antibody signatures in recombinant form.
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To report the clinical, radiological, and immunological association of demyelinating disorders with anti–N‐methyl‐D‐aspartate receptor (NMDAR) encephalitis.
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TLDR
Paraneoplastic neurologic syndromes are incited by a tumor outside the nervous system that produces a characteristic antigen of the nervous System that damages nerve tissue and inhibits growth of the tumor.
Anti‐LGI1 encephalitis is associated with unique HLA subtypes
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This work investigated whether AE is associated with the human leukocyte antigen (HLA) subtypes and found that it is not associated with either of the two subtypes.
Antibodies to the GABAB receptor in limbic encephalitis with seizures: case series and characterisation of the antigen
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GABA(B) receptor autoimmune encephalitis is a potentially treatable disorder characterised by seizures and, in some patients, associated with small-cell lung cancer and with other autoantibodies.
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In this cohort study, anti-CASPR2 antibodies in the CSF are associated with a subtype of autoimmune encephalitis with prominent limbic involvement and seizures that is rarely associated with cancer.
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TLDR
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Herpes simplex virus‐induced anti‐N‐methyl‐d‐aspartate receptor encephalitis: a systematic literature review with analysis of 43 cases
To conduct a systematic literature review on patients with biphasic disease with herpes simplex virus (HSV) encephalitis followed by anti‐N‐methyl‐D‐aspartate receptor (NMDAR) encephalitis.
Human cerebrospinal fluid monoclonal N-methyl-D-aspartate receptor autoantibodies are sufficient for encephalitis pathogenesis.
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Functional data using primary hippocampal neurons indicate that human cerebrospinal fluid-derived monoclonal NR1 antibodies alone are sufficient to cause neuronal surface receptor downregulation and subsequent impairment of NMDAR-mediated currents, thus providing ultimate proof of antibody pathogenicity.
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