Antibody GD3G7 selected against embryonic glycosaminoglycans defines chondroitin sulfate-E domains highly up-regulated in ovarian cancer and involved in vascular endothelial growth factor binding.

@article{Dam2007AntibodyGS,
  title={Antibody GD3G7 selected against embryonic glycosaminoglycans defines chondroitin sulfate-E domains highly up-regulated in ovarian cancer and involved in vascular endothelial growth factor binding.},
  author={Gerdy B. ten Dam and Els M A van de Westerlo and Anurag Purushothaman and Radu V Stan and Johan Bulten and Fred C G J Sweep and Leon F A G Massuger and Kazuyuki Sugahara and Toin H van Kuppevelt},
  journal={The American journal of pathology},
  year={2007},
  volume={171 4},
  pages={1324-33}
}
Chondroitin sulfate (CS) is abundantly present in the tumor stroma, and tumor-specific CS modifications might be potential targets to influence tumor development. We applied the phage display technology to select antibodies that identify these tumor-specific CS modifications. Antibody GD3G7 was selected against embryonic glycosaminoglycans, and it reacted strongly with CS-E (rich in GlcA-GalNAc4S6S units). In ovarian adenocarcinomas, strong expression of this CS-E epitope was found in the… CONTINUE READING