Antibody Fab assembly: the interface residues between CH1 and CL.

@article{Padlan1986AntibodyFA,
  title={Antibody Fab assembly: the interface residues between CH1 and CL.},
  author={Eduardo A. Padlan and Gerson H Cohen and D. Roy Davies},
  journal={Molecular immunology},
  year={1986},
  volume={23 9},
  pages={951-60}
}
The effective assembly of an antibody molecule requires the proper association of the light and heavy chains, namely the tight, canonical association of VH with VL, and of CH1 with CL. In this paper the interaction of CH1 is examined by looking at the degree of conservation of residues in the interface between CH1 and CL, where CH1 can belong to any of the heavy chain classes, and CL can be either lambda or kappa. The three-dimensional structures of four antibody Fabs have been examined to see… CONTINUE READING